Over time, we've been told many different things relating to the best number of sets for optimal muscle growth.

Some say that just one set is enough to induce muscle growth, while others insist multiple is required. 

Well luckily there's plenty of science to draw upon here, that will leave you forming an opinion of your own.

Let me present you with the facts!

GAIN MUSCLE: HOW MANY SETS FOR MUSCLE GROWTH?

A recent meta-analyis examined this topic (1).

A meta-analysis is when scientific researchers examine a load of studies into a particular topic and draw a conclusion - just what we're after.

This meta-analysis examined 8 studies and concluded that:

"Multiple sets (2-3 sets) are associated with 40% greater hypertrophy-related effect sizes than 1 set, in both trained and untrained subjects."

So is this it?

Common sense right? More sets lead to more muscle growth?

So do we shut the books, go off and train with multiple sets and never think about it again? 

Well, not quite.

Following this meta-analysis in 2010, the author was criticised by many other researchers for summarising such a perplexing topic with a simple statistic so easily, and leaving other studies out. (2).

But the point is, there was some evidence in some studies to suggest that multiple sets were better - that much we can't ignore.

GAIN MUSCLE: ONE SET FOR MUSCLE GROWTH? BODYBUILDING TIPS FOR YOUR FITNESS PLAN

Other evidence has found to the contrary; that one set is indeed beneficial and all that's needed for muscle growth.

In untrained subjects, one study (3) that examined 39 healthy untrained subjects found no significant difference between the 1 set group or the 3 set group in the context of a leg workout.

Other research however has found in favour of 3 sets over 1 set in the context of bicep training in untrained young Japanese men (4).

Each person trained twice a week, performing 1 set of bicep curls on one arm and 3 sets on the other at 80% of their 1RM to muscle failure.

They found a statistical significance in muscle growth for BOTH groups over the 12 week period, with a statistically significant difference in size and strength for the 3 set group.

GAIN MUSCLE: HOW MANY SETS FOR MUSCLE GROWTH - TRAINED SUBJECTS?

I know I know, I can hear you screaming from here, "what about trained subjects?"

Research divided 35 trained males into 3 groups - the 1 set, 2 set or 4 set group (5).

This meant they did 3, 6 or 12 sets per muscle group. They did 4 different sessions a week for 10 weeks; legs, back, chest and shoulders, back and calves, and biceps and triceps. 

An ultrasound determined muscle gains in the rectus femoris (legs) and the triceps (arms).

And was there any significant difference between muscle growth for the groups?

No.

Now this is a well designed piece of research - mirroring what most of us at the gym are doing - agreed?

Another study into untrained subjects compared 3 sets of leg extensions and 1 set of elbow flexion, to 1 set of leg extensions 3 sets of elbow flexion (6). 

Now that's a good design!

And what did the authors conclude?

No significant differences in either group for the leg extensions, and would you believe - no increases in muscle mass for them at all!

So maybe volume for legs is important?

It certainly seems that way, and might explain why cyclists, who obviously subject their quads to large amounts of volume have such thick quadriceps!

However, this hypothesis is obviously beyond the scope of this article and one that I haven't yet investigated. 

But back to the study, and how did the elbow extensions go?

Well, there was a 7.2% increase for the 1 set group, and a 5.9% increase for the 3 set group, which led the authors to conclude:

"Single-set training protocols might be sufficient for increasing strength and muscle thickness of the elbow flexors..."

BODYBUILDING TIPS FOR YOUR FITNESS PLAN: HOW MANY SETS FOR MUSCLE GROWTH THEN?

Obviously the results are conflicting and there's no absolute final decision here unfortunetly.

But for trained subjects, which is most of us, there does seem to be some solid evidence that 1 set for the exercises you chose might be enough (5).

But it does seem in some cases that more is not more. 

Again looking at untrained subjects, research has found that when a group did either bench press and lat pull downs, or bench press, lat pulldowns together with tricep extensions and elbow flexion exercises, there was no difference.

They performed for 3 sets of 8-12 reps twice a week for 10 weeks - but obviously in the second group - they isolated the biceps and triceps, so the volume was greater.

And amazingly there was no difference in muscle growth between the groups, suggesting that when you work the biceps during a back workout and the triceps during a chest workout when you're untrained - that's suffice for growth in both those muscle groups, and you might not need to add on isolated exercises at the end.

BODYBUILDING TIPS FOR YOUR FITNESS PLAN: WHAT YOU SHOULD TAKE-AWAY

It seems that to be safe, multiple sets could still be recommended. 

However, we cannot ignore the evidence into trained and untrained subjects, that 1 set alone may be suffice for optimal muscle hypertrophy. 

Maybe we could walk away with this - when you're strapped for time, push to absolute muscle failure for a chosen muscle group for just the ONE set for 4-5 exercises.

When your gym pals wonder why the hell you were so quick, you can kindly point them to this article, as you bolt out the door with just possibly the same amount of muscle growth as them, despite their seemingly endless number of sets!

 

"Stay Fit, Stay Flexed!"

 

REFERENCES

(1) Krieger JW. Single vs. multiple sets of resistance exercise for muscle hypertrophy: a meta-analysis. J Strength Cond Res. 2010 Apr;24(4):1150-9. doi: 10.1519/JSC.0b013e3181d4d436.

(2) Fisher J. Beware the meta-analysis: Is multiple set training really better than sinlge-set training for muscle hypertrophy? Journal of Exercise Physiology. December 2012, Volume 15, number 6.

(3) Starkey DB, Pollock ML, Ishida Y, et al. Effect of resistance training volume on strength and muscle thickness. Med Sci Sports Exerc 1996; 28(10): 1311-20. 
 
(4) Sooneste H, Tanimoto M, Kakigi R, et al. Effects of training volume on strength and hypertrophy in young men. J Strength Cond Res 2012; 27(1): 8-13. 
 
(5) Ostrowski KJ, Wilson GJ, Weatherby R, et al. The effect of weight training volume on hormonal output and muscular size and function. J Strength Cond Res 1997; 11(1):148-54. 
 
(6) Bottaro M, Veloso J, Wagner D, et al. Resistance training for strength and muscle thickness: Effect of number of sets and muscle group trained. Sci Sports 2011; 26: 259-64.